Professor of Pathology & Laboratory Medicine
University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania
Don Siegel, Ph.D., M.D. is Professor of Pathology & Laboratory Medicine and founding director of the University of Pennsylvania’s Division of Transfusion Medicine & Therapeutic Pathology. He directs Penn’s Center for Advanced Cellular Therapies which has manufactured over 3000 cell products including the first genetically modified cell therapy product approved by the FDA (tisagenlecleucel, Kymriah®) and first-in-human use of CRISPR-edited cells.
Dr. Siegel’s laboratory has been funded by the NIH in the areas of immunohematology, hemostasis/thrombosis, autoimmunity, and oncology since 1992. His laboratory focuses on the discovery of recombinant antibodies relevant to transfusion medicine, benign hematology, infectious diseases, and oncology, particularly for use in the design of targeted therapies such as CAR T-cells.
Since 2017, Dr. Siegel has been recognized with the RISE Award, the Dale E. Smith Memorial Award, the Tibor Greenwalt Memorial Award and Lectureship, the Emily Cooley Memorial Award and Lectureship, and election to the NBF Hall of Fame from the AABB, and the Francis S. Morrison Award and the Lecturer Award from ASFA. For contributions to the development of CAR T-cell therapy, Dr. Siegel shared the 2020 Robert de Villiers Spiral of Life Award from the Leukemia Lymphoma Society and the 2020 Society for the Immunotherapy of Cancer Team Science Award.
Dr. Siegel received an undergraduate degree in Biophysics from Brown University, a Ph.D. in Biophysics from Harvard University, and an M.D. from UPenn. He completed a residency in Clinical Pathology and Fellowship in Transfusion Medicine at UPenn before joining as a member of the faculty.
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Sunday, October 18, 2026
2:00 PM - 3:00 PM EST
AM26-MO-36-L - The Next Frontier: Advances in Car-t & Gene Therapy
Monday, October 19, 2026
4:30 PM - 5:30 PM EST