Assistant Professor, Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts
My scientific research program seeks to answer fundamental questions that lie at the intersection of transfusion medicine, immunology and glycobiology. As I have trained independently in each of these areas, first as a graduate student focused on glycobiology and innate immunity against microbial species and then as a post-doctoral fellow focusing on the development of adaptive immune responses to red blood cell (RBC) glycoproteins, I have found these fields to be intimately related. Throughout my graduate and post-graduate training I developed a strong foundation of scientific knowledge and technical expertise in each of my scientific areas of interest; this has resulted in a strong foundation for my independent research program focused on elucidation of key concepts in the immune regulation of alloimmunization to blood borne antigens, including key interactions with microbial populations that shape underlying immune environments in which blood borne antigens are encountered.
In addition, throughout my research career I have found tool development to be one of the key aspects that promote advancement of any field, and my chosen fields of transfusion medicine and glycobiology are no exception. For this reason, I have placed significant focus on the development of key tools, including development of microarray approaches and tools in immunology that will provide a strong technical foundation to my area of research. Through studies that utilize this powerful array of tools, ranging from high-throughput microarray technology to classic microbiology and immunology techniques and unique mouse models, we have begun to shape an intriguing picture of the array of players that shape both the formation and clinical consequence of alloimmune responses to blood borne antigens. I look forward to lending my expertise in tool development and transfusion medicine in general to help make this proposed session a success.
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