AM26-MO-16-L - Understanding Models of Transfusion Medicine

Monday, October 19, 2026

2:00 PM - 3:00 PM EST

Room: GWCC B312-B313A

Program Chair(s)

CA

Connie Arthur, PhD

Assistant Professor, Department of Pathology
Brigham and Women's Hospital
Boston, Massachusetts

No Financial Relationship to Disclose.

Speaker(s)

Rachael P. Jackman, PhD (she/her/hers)

Associate Investigator, Vitalant Research Institute; Adjunct Associate Professor, USCF
Vitalant Research Institute; Department of Laboratory Medicine, University of California, San Francisco
San Fransisco, California

Disclosure(s): No financial relationships to disclose.
Moritz Stolla, MD

Director for Platelet Transfusion Research, Associate Professor
Bloodworks Northwest Research Institute, Seattle, WA
Seattle, Washington

Disclosure(s): No relevant disclosure to display.

Disclosure(s):

Rachael Jackman, PhD: No financial relationships to disclose.

Moritz Stolla, MD: No relevant disclosure to display.

Proposed Session Description: The effective use of model systems for studies in transfusion medicine is key to advancement in the field. Moreover, a clear understanding of such model systems is critical for responsible and effective literature review by both physicians and researchers seeking to contextualize new scientific discoveries with the potential to positively shape patient care. Well-established in vitro and in vivo preclinical models have reliably provided critical insight for many years that has progressed clinical practice significantly and will continue to do so. More recently, however, scientific advance has allowed for development of various alternative models, including advanced culture techniques, organoid development, and the regular use of bioinformatic and AI modeling for mechanistic insight into targeted approaches for more efficient experimental design. Given the recent NIH push for the replacement of animal models, this session will explore alternatives to these more established transfusion models, highlighting strengths and weaknesses of both old and new models and exploring the appropriate utility of each.

Learning Objectives:

Recognize the model systems that drive scientific discovery for the advancement of patient care in transfusion medicine.
Summarize the strengths and weaknesses of each model system to understand its appropriate utilization.
Apply appropriate interpretation of data generated through various model systems for responsible literature review that can provide an accurate understanding and up to date knowledge of transfusion related scientific advances.